FX1 is a Specific BCL6 Inhibitor for Lymphoma Research
Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. Mutations in BCL6 can lead to B cell lymphomas because it promotes unchecked B…
Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. Mutations in BCL6 can lead to B cell lymphomas because it promotes unchecked B…
The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, growth, and cell cycle progression. Specifically, it composes two parts: PI3K…
SYK is a non-receptor tyrosine kinase. Specifically, Syk is a key element in the B cell receptor signaling pathway. Besides, Syk is also a key component of signal transduction in…
Oral squamous cell carcinoma (OSCC) is one of the most prevalent and fatal oral cancers. Mitochondria-targeting therapies represent promising strategies against various cancers. Alantolactone (ALT) possesses anticancer properties and also…
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, there are four known types of adenosine receptors in humans:…
The double stranded nature of DNA creates a special set of problems for processes that require strand unwinding such as transcription and replication. The unwinding that occurs during these processes…
In humans, the hypothalamic-pituitary-gonadal (HPG) axis is critical for reproduction and the expression of sexual characteristics. The central regulator of the HPG axis is gonadotrophin-releasing hormone (GnRH). GnRH, a hormone…
Hedgehog is important for the organogenesis of almost all organs in mammals, as well as in regeneration and homeostasis. Sonic Hedgehog (Shh) pathway is important for the evolution of radio…
Receptor tyrosine kinases (RTKs) are a subclass of tyrosine kinases that play imporrtant role in mediating cell-to-cell communication and controlling a wide range of complex biological functions, including cell growth,…
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia, which defined as a minimum of 5 × 109/L monoclonal B cells in the blood. However, CLL affects approximately…