USL311 is a Selective CXCR4 Antagonist, with Anti-Tumor Activity
Cancer is most serious diseases as we often mentioned in our blog. It involves abnormal cell growth. These cells have the potential to invade or spread to other parts of…
Cancer is most serious diseases as we often mentioned in our blog. It involves abnormal cell growth. These cells have the potential to invade or spread to other parts of…
Wnt/β-catenin signaling is activated in over 90% of human colorectal cancer. In particular, loss-of-function mutations of the tumor suppressor adenomatous polyposis coli (APC), a key negative regulator of Wnt/β-catenin signaling,…
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, which belongs to the insulin receptor kinase subfamily. ALK correlates with oncogenesis in different types of cancers, such as anaplastic large-cell…
Sirtuins are NAD-dependent deacetylases that are involved in physiologic processes. To date, seven mammalian sirtuins have been identified (SIRT1–SIRT7). Sirtuin 1 (SIRT1) is a member of the sirtuin family of…
Non-Homologous End-Joining (NHEJ) is the important and crucial pathway for the repair of DNA double strand breaks (DSBs) in human cells. The NHEJ pathway is frequently upregulated in solid tumors…
Leukemia is a group of blood cancers, such as acute leukemia, as we mentioned in our previous blog “BSc5371, an Irreversible FLT3 Inhibitor for Acute Leukemia Treatment”. Multiple myeloma is…
Acute leukemia is a kind of serious diseases, includes acute myeloid leukemia, acute lymphoblastic leukemia and blast crisis of chronic myelogenous leukemia. MLL1 (Mixed-lineage leukemia 1; KMT2A) is a histone…
Chronic myeloid leukemia (CML) is a white blood cell disorder, accounting for about 15% of adult leukemias. The critical driving force of pathogenesis of CML identified is BCR gene and…
Glioblastoma multiforme (GBM) are highly malignant and invasive tumors. It not only can prevent total surgical resection, but also render these neoplasms refractory to cheJR-AB2-011 is a selective mTORC2 inhibitor…
Nerves carry messages from the brain to the rest of the body. Peripheral neuropathy occurs when the peripheral nervous system is damaged. Chemotherapy-induced peripheral neuropathy is one of the most commonly…