GNE-618 is a Orally Active NAMPT Inhibitor
Nicotinamide adenine dinucleotide (NAD) is a critical metabolite for a range of cellular reactions. NAD is an essential coenzyme involved in cellular redox reactions and is a substrate for NAD-dependent…
Nicotinamide adenine dinucleotide (NAD) is a critical metabolite for a range of cellular reactions. NAD is an essential coenzyme involved in cellular redox reactions and is a substrate for NAD-dependent…
The microtubules act as an attractive target for anticancer drug discovery nowadays. Disruption of microtubules can induce cell cycle arrest in the G2-M phase and formation of abnormal mitotic spindles.…
Hepatocellular carcinoma (HCC) is one of the most common cancers. Combating hepatocellular carcinoma invasion and metastasis has become a major desire in hepatocellular carcinoma patients. CD147 (also called EMMPRIN) is…
The human mitochondrial enzyme, called methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), plays a key role in one-carbon metabolism in purine or thymidine biosynthesis. In mitochondrial folate carbon metabolism, MTHFD2 has attracted considerable…
The cell-division cycle protein 20 (Cdc20) is the substrate receptor of anaphase synthesis complex (APC) or cyclosome (APC/C). Besides, it coordinates late initiation and exit of mitosis through safety and…
The ErbB tyrosine kinase receptor (RTK) family has 4 members: ErbB1 (EGFR/HER1), ErbB2 (HER2/neu), ErbB3 (HER3), and ErbB4 (HER4). These receptors are cell surface receptors and play important roles in…
KRAS mutations are the most common mutations. Especially, the KRAS oncogene encodes a binding protein that plays a crucial role in transmitting signals from extracellular growth factors to the cell…
The stimulator of interferon genes (STING) is an innate pattern recognition receptor natively exists in the endoplasmic reticulum (ER). STING has a great effect on host defense through supervising pathogenic…
Mesenchymal stem cells (MSCs) are multipotent progenitor cells that play a critical role in tissue regeneration. MSCs play an important role in matrix remodeling, fibroblast activation, angiogenesis, and immunomodulation. MSCs…
As we all know, angiogenesis plays an essential role in the physiology of neonatal development, reproduction, and wound healing. PDGF-BB (Platelet-derived growth factor-BB ) is a mitogenic factor for smooth…