CKI-7 is a Dual CK1 and Cdc7 Kinase Inhibitor
Protein phosphorylation plays a fundamental role in the regulation of a variety of cellular processes. Casein kinase I (CK1) is a cyclic nucleotide independent kinase. It is highly purified from…
Protein phosphorylation plays a fundamental role in the regulation of a variety of cellular processes. Casein kinase I (CK1) is a cyclic nucleotide independent kinase. It is highly purified from…
Conventional chemotherapy and radiation induce more and more breast cancer stem cells (BCSC) resistance. In recent years, increasing studies have suggested that the dysregulation of Wnt/β-catenin signaling occurs in breast…
DNA repair is very important for the maintenance of genome integrity in all organisms. Different exogenous agents or genotoxic products of metabolism cause multiple DNA repair systems evolved to eliminate…
Interleukin-1 receptor-associated kinase 4 (IRAK4) is the most upstream kinase in Toll/Interleukin-1 receptor (TIR) signaling. Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling in a variety of myeloid and lymphoid…
There are reports of YES1 participating in numerous signaling pathways. SRC is a nonreceptor protein tyrosine kinase and is encoded by a proto-oncogene. Besides, the nine members of the SRC…
DDB1-CUL4-associated protein 16 (DCAF16) is a 216 aa protein that is highly conserved across mammals, but absent from rodents. The DCAF16 protein has eight cysteine residues, including a cluster of…