Tetrac is a Thyrointegrin Receptor Antagonist
In the angiogenesis process, integrins are members of a family of cell surface transmembrane receptors. They play a critical role particularly in blood vessel formation and the local release of…
In the angiogenesis process, integrins are members of a family of cell surface transmembrane receptors. They play a critical role particularly in blood vessel formation and the local release of…
Integrins are heterodimeric cell surface adhesion receptors that consist of two noncovalently associated alpha and beta subunits. In particular, Integrins are heterodimeric transmembrane proteins composed of one α and one…
Vascular endothelial growth factor (VEGF) is a prime contributor to tumor angiogenesis. Most tumor cells produce high levels of VEGF and VEGF receptors associated with tumor endothelial cells. E7820 is…
Increasing evidence indicated that targeting tumor angiogenesis for specific drug transfer into tumor masses and metastasis is a promising approach. On the one hand, integrin poorly expressed on quiescent vessels…
Conventional small-molecule probes play their roles by perturbing the functions of proteins, including blocking enzyme catalysis or antagonizing receptor signaling. However, a compound only binds to only one of these…
BCL6 (B-cell lymphoma 6 protein) is a transcriptional repressor. Strikingly, this protein plays a key role in the formation and maintenance of germinal centers during the process of antibody affinity…