ML339 is a Selective CXCR6 Antagonist
Prostate cancer is cancer that occurs in the prostate. Prostate cancer is the second-leading cause of cancer deaths for men. Especially, Prostate cancer is one of the most common types…
Prostate cancer is cancer that occurs in the prostate. Prostate cancer is the second-leading cause of cancer deaths for men. Especially, Prostate cancer is one of the most common types…
NSD2 (nuclear receptor-binding SET domain-containing 2) is a protein lysine methyltransferase. It belongs to the NSD family, which also includes NSD1 and NSD3, and that predominantly mono- and dimethylates lysine…
SH2 containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase. SHP2 facilitates growth and survival signaling downstream of numerous receptor inputs. In addition, higher levels of SHP2 phosphorylation associate with…
Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling. It is critical for the proliferation and survival of leukemic cells in many B…
Akt1 belongs to the Akt subfamily of serine/threonine kinases, which contains the SH2 (SRC homologous 2-like) domain. Specifically, Akt kinase is the central node of the signal transduction pathway, which…
Programmed cell death 1 (PD-1) is a cell surface receptor. PD-1 is highly expressed on tumor-specific T cells. It is a T cell checkpoint and plays a central role in…
Chemotherapy is a cornerstone in the development of present-day cancer therapy. Moreover, Chemotherapy is one of the most effective and potent strategies to treat malignant tumors. However, Chemotherapy resistance occurs…