Ceritinib is an Orally Active ALK Tyrosine Kinase Inhibitor for Kinds of Cancers Research
Ceritinib is an orally active ALK tyrosine kinase inhibitor for kinds of cancers research.
Ceritinib is an orally active ALK tyrosine kinase inhibitor for kinds of cancers research.
Bruton’s tyrosine kinase (BTK) is a key regulator of the B-cell receptor signaling pathway, and aberrant B-cell receptor (BCR) signaling has been implicated in the survival of malignant B-cells. However,…
Amcenestrant is an orally active, nonsteroidal and selective estrogen receptor degrader (SERD) for breast cancer research.
Tyrosine kinases are a family of enzymes, which catalyzes phosphorylation of select tyrosine residues in target proteins, using ATP. This covalent post-translational modification is a pivotal component of normal cellular…
Colorectal cancer represents 15% of all cancers in Western countries, and is the most frequently observed. Nowadays, colorectal cancer is the world's fourth most deadly cancer with almost 900,000 deaths…
PI3K has four isoforms, PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ. PI3K plays an important role in cell proliferation, survival, differentiation, migration and angiogenesis. Moreover, Several processes can lead to the activation…
mTOR (mammalian target of Rapamycin) is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. mTOR belongs to the phosphatidylinositol 3-kinase-related…
T cells are important immune cells in the human body and express co-stimulating immune checkpoint proteins on their surface. Through immune checkpoints, cancer cells can block the activation of T…
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein. And it is a receptor for members of the epidermal growth factor family (EGF family) of…
Pancreatic cancer is an extremely lethal disease with a poor prognosis. Traditional chemotherapeutic agent could improve the prognosis of the pancreatic cancer. For example, poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi)…