FX1 is a Specific BCL6 Inhibitor for Lymphoma Research
Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. Mutations in BCL6 can lead to B cell lymphomas because it promotes unchecked B…
Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. Mutations in BCL6 can lead to B cell lymphomas because it promotes unchecked B…
Receptor tyrosine kinases (RTKs) are a subclass of tyrosine kinases that play imporrtant role in mediating cell-to-cell communication and controlling a wide range of complex biological functions, including cell growth,…
Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Antifolates act specifically during DNA and RNA synthesis, exerting a cytotoxic…
Ceritinib is an orally active ALK tyrosine kinase inhibitor for kinds of cancers research.
Bruton tyrosine kinase (Btk) is a member of the Tec family kinases with a well-characterized role in B-cell antigen receptor (BCR)-signaling and B-cell activation. Btk plays a crucial role in…
PI3K (Phosphoinositide 3-kinase) are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). Class I PI3K…
PI3K has four isoforms, PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ. PI3K plays an important role in cell proliferation, survival, differentiation, migration and angiogenesis. Moreover, Several processes can lead to the activation…
As we know, Bruton tyrosine kinase (Btk) is a member of the TEC family kinases. In addition, it is involved in B-cell antigen receptor (BCR)-signaling pathway. Usually, BTK is expressed…
Bruton tyrosine kinase (Btk), a non-receptor kinase, is a member of the Tec family kinases. Btk is exists in B cells and myeloid cells. Btk has a carboxy-terminal catalytic domain…
IL-15 is an inflammatory cytokine, as well as an activator of T cells and natural killer (NK) cells. It binds to and signals in a complex consisting of the IL-2/IL-15 receptor…