NVS-CECR2-1 is a CECR2 BRD (non-BET Family) Inhibitor
A Bromodomain (BRD) is a protein domain of about 110 amino acids and is a "reader" of lysine acetylation. Specifically, BRDs recognize acetylated lysine residues, such as those on the…
A Bromodomain (BRD) is a protein domain of about 110 amino acids and is a "reader" of lysine acetylation. Specifically, BRDs recognize acetylated lysine residues, such as those on the…
Knowledge of the pathogenesis of AML has seen great progress due to recent advances in genetic studies. However, the long-term survival of AML patients is still unsatisfactory. A block in…
PROteolysis Targeting Chimeras (PROTACs) regulate protein function by degrading target proteins instead of inhibiting them, providing more sensitivity to drug-resistant targets. PROTACs show better selectivity compared to classic inhibitors. PRTOACs…
CDKs remain attractive targets for anti-proliferative cancer chemotherapy. they play a central role in cell division and growth. Amongst the cell cycle CDKs, CDK2 has attracted the most attention and…
Hu antigen R (HuR) is an RNA binding protein. Specifically, Its overexpression in human cancer is associated with aggressive disease, drug resistance, and poor prognosis. HuR is highly abundant in…
Poly(ADP-ribose) polymerase (PARP) is an important protein in DNA repair pathways especially the base excision repair. . PARP proteins compose of two ribose moieties and two phosphates per unit polymer.…
Lung cancer continues to be the leading cause of cancer-related mortality. Members of the ERBB receptor tyrosine kinase family include EGFR, HER2, HER3, and HER4. They present an attractive option…
DNA2 nuclease possesses 5′ flap endonuclease and 3′-5′ helicase activities. It has an important role in DNA damage repair, homologous recombination, and DNA replication. The nuclease activity of DNA2 has…
The mitogen-activated protein kinase (MAPK) signal pathway plays an important role in cells. It also has a response to many different external stimuli and regulates cellular growth, proliferation. The Raf…
Diacylglycerol kinase (DGK) is a second messenger in its own right and can modulate the activity of PKC and several ion channels. Chemokines are low MW extracellular signaling peptides secreted…