Amcenestrant is an Orally Active SERD for Breast Cancer Research
Amcenestrant is an orally active, nonsteroidal and selective estrogen receptor degrader (SERD) for breast cancer research.
Amcenestrant is an orally active, nonsteroidal and selective estrogen receptor degrader (SERD) for breast cancer research.
BCR-ABL tyrosine kinase, an abnormal fusion protein kinase, is associated with pathogenesis of chronic myelogenous leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL). Usually, BCR-ABL is overexpressed with CML stem…
They key toxic component of oleander is oleandrin. It only accounts for 0.08 % of total cardenolides and have a bioavailability of 30 %. The yellow flowered oleander contains Peruvoside.…
Breast cancer is the most common cancer in women all over the world. Breast cancer development is associated with abnormal cell proliferation and defects in apoptosis. Noticeably, Polo-like Kinases (PLKs)…
Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) play a crucial role in angiogenesis and angiogenesis. Specifically, the VEGF family includes VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor…
PLK4 (polo-like kinase 4) is an enzyme that encodes a member of the polo family of serine/threonine protein kinases. Importantly, PLK4 protein localizes to centrioles—complex microtubule-based structures found in centrosomes-and…
Pegdinetanib (BMS-844203), an anti-angiogenic therapeutic agent, exemplifies a new class of targeted biologics called Adnectins. Adnectins are genetically engineered variants of the tenth type III domain of human fibronectin. Firstly,…
Melanoma is a type of skin cancer that is caused by a malignant proliferation of melanocytes. Ultraviolet light (UV) exposure can change DNA and its expressions and is the primary…
Bax, an important regulator of cell death is expressed in essentially all organs. Also, Bax is a member of B-cell lymphoma 2, it is involved in the apoptosis of normal…
Nowadays, how to overcome the resistance of tumor cells to multiple drugs is still a serious problem. Various mechanisms can cause Multidrug resistance (MDR), including cell cycle alterations, increased repair…