NVS-CECR2-1 is a CECR2 BRD (non-BET Family) Inhibitor
A Bromodomain (BRD) is a protein domain of about 110 amino acids and is a "reader" of lysine acetylation. Specifically, BRDs recognize acetylated lysine residues, such as those on the…
A Bromodomain (BRD) is a protein domain of about 110 amino acids and is a "reader" of lysine acetylation. Specifically, BRDs recognize acetylated lysine residues, such as those on the…
Brominedomain can recognize acetylated lysine residues. As the "reader" of lysine acetylation, the bromine domain is responsible for the transduction of signals carried by acetylated lysine residues and transforming them…
Bromodomains (BrDs) in transcription proteins bind acetyl-lysine in histones and transcription factors to direct gene transcription in biology and disease conditions. BRD4 contains two characteristic tandem BrDs. Meanwhile, BRD4 is…
PROTACs (proteolysis-targeting chimeras) are bifunctional molecules that bring a target protein into spatial proximity with an E3 ubiquitin ligase to trigger target ubiquitination and subsequent proteasomal degradation. PROTAC recruits BRD4…
BRD4 (Bromodomain-containing protein 4) belongs to the BET family, which also contains BRD2, BRD3, and BRDT. BRD4 has two bromodomains to recognize acetylated lysine residues. They are BD1 and BD2.…
MZP-55 is a selective PROTAC degrader of BRD3/4, shows no obvious effect on BRD2. MZP-55 exhibits excellent activity in cancer research. PROTAC (proteolysis targeting chimera) is a chimera, functions to…