Trilaciclib is a CDK4/6 Inhibitor for Kinds of Cancer Research
CDK4/6 is a Ser/Thr protein kinase that is active only in the G1-S phase. It is controlled by the regulatory subunit D-type cyclin and the CDK inhibitor p16INK4a; involved in the…
CDK4/6 is a Ser/Thr protein kinase that is active only in the G1-S phase. It is controlled by the regulatory subunit D-type cyclin and the CDK inhibitor p16INK4a; involved in the…
CDKs (Cyclin-dependent kinases) are the families of protein kinases first discovered for their role in regulating the cell cycle. By definition, a CDK binds a regulatory protein called a cyclin.…
The cell cycle is a highly conserved process. Additionally, this process must maintain genomic integrity and replicative capacity for proper cell maintenance and proliferation. The cell cycle consists of four…
The chimeric proteolytic enzyme (PROTAC) is a heterobifunctional small molecule. Specifically, it is composed of two active domains and an adaptor that can remove specific proteins that are not needed.…
Targeted protein degradation induced by PROTAC has become a new therapeutic strategy in drug development. Besides, PROTAC has two covalently linked protein binding molecules. One can bind E3 ubiquitin ligases…