ML-097 (CID-2160985) is a Pan Ras-related GTPases Activator
Ras, is a family of related proteins expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase. Furthermore,…
Ras, is a family of related proteins expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase. Furthermore,…
To date, we identified 167 small GTPases in humans which are key signal transducing enzymes. Small GTPases comprise five main families whose eponymous members are Ras, Rho, Rab, ADP-ribosylation factor…
Farnesyl transferase (FTase) is a zinc-dependent enzyme, which coordinates a zinc cation on its β subunit at the lip of the active site. FTase has two subunits: a 48kDa α-subunit…
Medullary thyroid cancer is a form of thyroid carcinoma which originates from the parafollicular cells, which produce the hormone calcitonin. Synthetic tailoring of approved drugs for new indications is often…
Ras is a small GTPase and interacts with the protein Raf to create activated Ras-Raf complex that activates the downstream effectors in the ERK pathway. Malfunctioning Ras-Raf switches cause cancer.…
Alteration of small GTPase functions is a hallmark of genetic and sporadic human diseases, making GTPase family members attractive though understudied targets. Specifically, the Ras superfamily of GTPases includes Arf,…
The RAS/RAF/MEK/ERK (MAPK) signal transduction pathway has attracted significant interest as a therapeutic target for cancer. ERK1/2 phosphorylates more than 50 downstream substrates responsible for cell growth, proliferation, survival, angiogenesis,…
Members of the RAS family of GTPases (which comprises KRAS, NRAS, and HRAS) are major oncogenes. Especially, mutations in the RAS genes are major oncogenes with a high occurrence rate…