A947 is a Selective and Efficacious SMARCA2 PROTAC in SMARCA4 Mutant Cancers
SWI/SNF complex has two important ATP-dependent helicases, SMARCA2 and SMARCA4. In fact, SMARCA2 and SMARCA4 share strong protein sequence homology. But SWI/SNF helicase SMARCA4 is frequently mutated in cancer. The…