Carfilzomib is an Epoxykeytone Proteasome Inhibitor for Multiple Myeloma Research
Multiple Myeloma (MM) is characterized by the production of monoclonal immunoglobulin (Ig), which may be...
Multiple Myeloma (MM) is characterized by the production of monoclonal immunoglobulin (Ig), which may be...
CXCRs (CXC chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines...
HDAC inhibitors are a class of anticancer agents. HDAC inhibitors have shown antitumor effects in...
Aurora kinases belong to serine/threonine kinases. Aurora kinases control multiple events during cell cycle progression...
JNK is involved in regulating another mitochondrial protein cytochrome c during cell apoptosis. Specifically, Smac...
Proteolytic targeting chimera (PROTAC) is a heterobifunctional small molecule, including two active domains, and a...
Multiple myeloma represents a heterogeneous disease with various oncogenic mutations, chromosomal translocations, and copy number...
The hypoxic bone-marrow (BM) microenvironment confers growth/survival and drug-resistance in myeloma. Novel therapies via targeting...
Leukemia is a group of blood cancers, such as acute leukemia, as we mentioned in...
The multi-targeted receptor tyrosine kinase (RTK) family includes the receptors for insulin and for many...