Role of PRMT7 Probe SGC3027 in Cancer

Protein arginine methyltransferases (PRMTs) transfer methyl groups to the arginine residues of histones and other proteins. Fistly, PRMTs add one or two mono-methyl groups to the guanidino nitrogen atoms of arginine residues. And secondly, PRMTs results in epigenetic modification of histones or changes of protein-protein interactions. Lastly, these interactions...

R916562, a Dual Axl/VEGF-R2 Inhibitor for Cancer Therapy

Axl tyrosine kinase is a putative driver of diverse cellular processes that are critical for the development, growth, and spread of tumors. It is a promising therapeutic target for cancer therapy. VEGFR2 is a primary responder to vascular endothelial growth factor signal, and thereby regulates endothelial migration and proliferation....

EC0489, a SMDC for Cancer Therapy

Small molecule drug conjugates (SMDCs) contain three parts: a targeting ligand, a linker and a drug payload. SMDCs have their own strengths such as manageable synthesis and a non-immunogenic nature. The molecular weights of SMDCs are potentially much lower, and lead to good cell penetration in tumors and better...