NRX-2663 is an Enhancer of the Interaction between β-Catenin and E3 Ligase
Protein-protein interactions (PPIs) play a key role in nearly every biological function. And PPIs are a promising new class of biological targets for therapeutic intervention. In addition, PPIs governing the recognition of substrates by E3 ubiquitin ligases are critical to cellular function. Using PPI enhancer molecules as a “molecular...
MSAB is a Selective Inhibitor of Wnt/β-Catenin Signaling
Wnt/β-catenin signaling regulates key cellular functions including proliferation, differentiation, migration, apoptosis, and stem cell renewal. The β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. In this study, researchers screen for small molecule compounds that act against Wnt/β-catenin...