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Prostate Cancer

ABBV-744 is a First-in-Class, Orally Active and Selective BET BDII Inhibitor

Louis Gilman July 20, 2021

The proteins of BET (bromodomain and extra-terminal) domain family are epigenetic readers. BET domain family proteins bind acetylated histones through their bromodomains to regulate gene transcription. BET domain family proteins…

Cancer

GSK973 is a Highly Selective BET BD2 Inhibitor

Louis Gilman May 19, 2021

The bromodomain and extra-terminal (BET) family of proteins are epigenetic readers of chromatin. The two tandem bromodomains (BD1 and BD2) of each of the four proteins (BRD2, 3, 4, and…

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Cancer

Irinotecan is a Topoisomerase I Inhibitor for Colorectal Cancer Research

Cancer Follicular Lymphoma Lymphoma

Copanlisib is a Pan-class I PI3K Inhibitor for Lymphoma Resaerch

NSCLC Pancreatic cancer

Erlotinib is an EGFR TKI for NSCLC and Pancreatic Cancer Research

B-cell malignancies

Parsaclisib is an Orally Active PI3Kδ Inhibitor for B-cell Malignancies Research

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