Bemcentinib (R428) is a Potent Axl Inhibitor for Cancer Research
Axl is a member of the TAM (Tyro3, Axl, Mer) receptor tyrosine kinase (RTK) family. Particularly, Axl involves in the stimulation of cell proliferation and survival. Besides, Axl signaling stimulates cellular responses, including activation of phosphoinositide 3-kinase-Akt, ERK, NF-κB pathway, and STAT signaling. Importantly, Axl is an inhibitor of...