PTC-028 is an Inhibitor of BMI-1 with Activity in Ovarian Cancer
Epithelial ovarian cancers are the most common type of ovarian cancer. BMI-1 over-expresses in epithelial ovarian cancer. Targeting BMI-1 sensitizes a variety of cancer cells to chemo-therapeutics. The B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) is a transcriptional receptor of the polycomb gene family. BMI-1 involves...