MC0704 is a STAT3 Inhibitor for Triple-negative Breast Cancer Research
Breast cancer (BC) is one of the main causes of cancer-associated death in women. And, BC is high recurrence and/or metastatic potential. BC is typically categorized into respective subtypes based on the presence of representative receptors (the human epidermal growth factor receptor, estrogen receptor, and progesterone receptor). Hence, these...
BPDA2 is a Highly Selective and Competitive SHP2 Inhibitor
SH2-containing protein tyrosine phosphatase 2 (SHP2) is a carcinogenic phosphatase. Specifically, SHP2 participates in the downstream signal transmission of various RTK. So it is the shared signal node for analysis. The phosphatase activity of SHP2 is necessary for important cancer-related signaling pathways (such as RAS and PI3K). Besides, the...
Elacestrant (RAD1901) is an Orally Available Estrogen Receptor Degrader
Breast cancer is subdivided into categories based on the tumor receptor status. Specifically, whether the tumor expresses estrogen receptor (ER), progesterone receptor (PR), or Her2. And, with ER+ disease makes up the majority of patients in the breast cancer patient population. Although there are currently available drugs against ER-positive...
MS8815 is a EZH2 PROTAC Degrader for Targeting Triple-Negative Breast Cancer (TNBC)
Enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of polycomb repressive complex 2 (PRC2). EZH2 drives oncogenesis not only in a canonical H3K27me3-dependent manner but also through non-canonical H3K27me3-independent functions. It exhibits overexpression in triple-negative breast cancer (TNBC). However, EZH2 catalytic inhibitors are ineffective in suppressing the...
CYD-4-61 is a Bax Activator Used for Breast Cancer Research
Bax is an apoptosis regulator, belonging to the Bcl-2-like protein family. It controls mitochondrial dysfunction and apoptosis. Bax can promote apoptosis by forming a heterodimer with Bcl-2 to become a lethal mitochondrial pore protein. Specifically, it can induce mitochondrial outer membrane permeability, release cytochrome c, and cause programmed death...
Serplulimab (HLX 10) is humanized monoclonal anti-PD-1 antibody
PD-1 (Programmed cell death protein 1; CD279) is an immune checkpoint. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily. Besides, It shows a role in regulating the immune system’s response by down-regulating the immune system. Meanwhile, this compound promotes self-tolerance by suppressing T-cell inflammatory activity....
ARV-471 is an Estrogen Receptor PROTAC Degrader for Breast Cancer
PROTAC is a heterobifunctional molecule containing two small molecule binding moieties. Specifically, PROTACs in cells seek and selectively bind to target proteins. PROTAC then recruits specific E3 ligases to the target protein. Besides, it forms a ternary complex in close proximity to the target protein and E3 ligase. In...