STING, refers to the stimulator of interferon genes, is an endoplasmic reticulum (ER) membrane-bound adapter protein. It binds to cGAMP and send a dramatic conformational change. Thereby STING triggers itself translocation from…
Breast cancer is the most common cancer in women all over the world. Breast cancer development is associated with abnormal cell proliferation and defects in apoptosis. Noticeably, Polo-like Kinases (PLKs)…
HDACs (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on histone. HDACs allow the histones to wrap the DNA more…
Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) play a crucial role in angiogenesis and angiogenesis. Specifically, the VEGF family includes VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor…
Breast cancer is the second most common cancer in the world. Although survival rates are constantly improving because of the current strategies of primary/secondary prevention and the availability of innovative…
Breast cancer is the most common malignancy in women, and one of the three most common cancers worldwide, along with lung and colon cancer. Metastases from breast carcinoma are formed…
CDK8 is a transcription-associated cyclin-dependent protein kinase (CDK) and also is a colorectal cancer oncogene. Cyclin C is a member of the cyclin family of proteins. Besides, Cyclin C interacts…
Axl is a member of the TAM (Tyro3, Axl, Mer) receptor tyrosine kinase (RTK) family. Particularly, Axl involves in the stimulation of cell proliferation and survival. Besides, Axl signaling stimulates…
Olinvacimab (TTAC-0001) is a fully human anti-VEGFR2 monoclonal antibody from a fully human naive single-chain variable fragment phage library. Olinvacimab (TTAC-0001) inhibits VEGF and binds to KDR with a Kd…
Breast cancer (BC) is one of the main causes of cancer-associated death in women. And, BC is high recurrence and/or metastatic potential. BC is typically categorized into respective subtypes based…