Lapatinib is a Potent Inhibitor of the ErbB-2 and EGFR Tyrosine Kinase Domains
Growth factors and their transmembrane receptor tyrosine kinase play important roles in cell proliferation, survival, migration, and differentiation. Additionally, Epidermal growth factor (EGF)-like proteins stimulates cells to divide by activating members of the EGF receptor (EGFR) family. Many types of human tumor cells growth and development are related to the...
β-Amanitin is a cyclic peptide toxin, inhibits eukaryotic RNA polymerase II and III and protein synthesis.
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. Besides, β-Amanitin inhibits eukaryotic RNA polymerase II and III. It inhibits DNA transcription and protein synthesis. Moreover, β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs). β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in...
H3B-5942, a Selective Estrogen Receptor Covalent Antagonist for ERα Breast Cancer Treatment
Estrogen receptor is a nuclear receptor activated by estrogen, existing inside cells. The receptor contains two types, ERα and ERβ. The former is always expressed in breast cancer, which causes great death among women around the world. Consequently, trying to find a potent ERα inhibitor is a possible...