Mitazalimab (ADC-1013) is a FcγR Crosslinking-dependent CD40 Agonist for Tumor Research
CD40 is a cell surface glycoprotein and type I transmembrane protein present in antigen-presenting cells (APCs). Also, its ligand CD40L (CD154) is mainly expressed on T cells and platelets. The combination activates APCs, including dendritic cells (DCs), B cells, macrophages, and so on. CD40 signaling can lead to the...