BSJ-4-116 is a Highly Potent and Selective PROTAC Based CDK12 Degrader
CDKs are serine/threonine protein kinases. They play major roles in regulating many different aspects of mammalian cellular function, most notably cell cycle and transcription. CDK12 is an emerging therapeutic target due to its role in regulating the transcription of DNA-damage response (DDR) genes. For example, ovarian and triple-negative breast...
SR-4835 is a Highly Selective and ATP Competitive Dual Inhibitor of CDK12/CDK13
Breast cancer is the most frequently diagnosed cancer of women worldwide. The feature of triple-negative breast cancers (TNBCs) is the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2/ERBB2) overexpression. Although early-stage TNBC responds well to treatment, the advanced disease is worse overall...