CM10 is a Selective Aldehyde Dehydrogenase 1A Family Inhibitor
The aldehyde dehydrogenase (ALDH) superfamily has 19 protein-coding family members with varying tissue or development expression. In addition, ALDHs metabolize endogenous and exogenous aldehydes to their corresponding carboxylic acids to prevent the accumulation of toxic aldehydes. Besides, ALDH1A enzymes are also involved in the biosynthesis of retinoic acid (RA)....
PTC596 is an Orally Active and Selective BMI-1 Inhibitor
BMI-1 is a highly conserved class II member of the Polycomb group of genes, regulating diverse aspects of transcription, stem cell maintenance, cell proliferation, and oncogenesis. BMI-1 has vital functions in the self-renewal and maintenance of AML and normal hematopoietic stem cells. The first BMI inhibitor PCT-209 has a...
KPT-6566 is a Selective PIN1 Inhibitor
PIN1 is a prolyl isomerase, which binds to several proteins, acts as a post phosphorylation control and regulates protein function. PIN1 targets proteins containing phosphorylated S/T-P sites firstly via the WW domain to bind to the protein. Next, the enzyme catalyzes the cis/trans isomerization via the catalytic PPIase domain....