OTS193320 is a SUV39H2 Methyltransferase Activity Inhibitor
SUV39H2 is a histone lysine-specific methyltransferase. Specifically, SUV39H2 introduced H3K9me3 to induce transcriptional inhibition. This plays a key role in heterochromatin maintenance, DNA repair, more recently, carcinogenesis. Besides, the genetic ablation of SUV39H1 and SUV39H2 genes leads to severe chromosome instability. For example, abnormally long telomeres are less bound...
Coleon-U-quinone is a Potent P-gp Inhibitor with Anti-Cancer Activity
Glycoprotein (P-gp) is an important protein of the cell membrane that pumps many foreign substances out of cells. Importantly, P-gp is an ATP-dependent efflux pump with broad substrate specificity. Besides, It exists in animals, fungi, and bacteria, and it likely evolved as a defense mechanism against harmful substances. Particularly,...