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Glioblastoma Multiforme Gliocytoma

GW2974 is an EGFR/HER2 Inhibitor for Glioblastoma Multiforme Research

Louis Gilman September 21, 2023

The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes. It plays an essential role in cardiac development during embryogenesis. Here, we will introduce…

autoimmune disease B-cell malignancies

BGB-8035 is an Orally Active BTK Inhibitor for B-cell Malignancies and Immunology Research

Louis Gilman June 19, 2023

Bruton tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in carcinogenic signaling. Meanwhile, it plays a central role in the signal transduction of B cell antigen…

Esophagus Cancer

Theliatinib tartrate is an Orally Active EGFR Inhibitor for Esophageal Cancer Research

Louis Gilman May 11, 2023

EGFR stands for epidermal growth factor receptor, a tyrosine kinase and transmembrane receptor protein. It primarily functions to regulate epithelial tissue development and homeostasis. Moreover, EGFR is a driver of…

Cancer Colon Cancer Colorectal Cancer Lung Cancer Non-Small Cell Lung Cancer

Izalontamab (SI-B001) is a Bispecific Anti-EGFR/HER3 mAb for Cancer Research

Louis Gilman March 15, 2023

EGFR (epidermal growth factor receptor) is a member of the ErbB receptor family1. Besides, EGFR is a common therapeutic strategy in epithelioma such as lung adenocarcinoma, colon cancer, head and…

Cancer Cancer Metastases

Cetuximab (C225) is an Anti-EGFR Monoclonal Antibody for Cancer Research

Louis Gilman March 3, 2023

EGFR (epidermal growth factor receptor) is a transmembrane protein and is a member of the ErbB family. Besides, EGFR is a protein tyrosine kinase expressed on many types of tumor…

Lung Cancer

Amivantamab (JNJ-61186372) is a Human EGFR-MET Bispecific Antibody

Louis Gilman January 16, 2023

Epidermal growth factor (EGF) is a protein that stimulates cell proliferation, differentiation, and survival by binding to its receptor EGFR. Additionally, It exists in platelets, urine, saliva, milk, tears, and…

Acute Leukemia Acute Myeloid Leukemia

JS25, a Selective and Covalent BTK Inhibitor, Acts by Segregating Tyr551

Louis Gilman November 26, 2022

BTK, Bruton’s tyrosine kinase, belongs to the cytoplasmatic kinases TEC subfamily. BTK involves in immune regulation, and is activated by Src kinases. Then BTK leads to phospholipase-Cγ (PLCγ) phosphorylation, Ca2+…

Lung Cancer

JBJ-09-063 is a Mutant-Selective Allosteric EGFR Inhibitor

Louis Gilman November 22, 2022

JBJ-09-063 is a mutant-selective allosteric EGFR inhibitor. And the IC50 values are 0.147 nM, 0.063 nM, 0.083 nM, and 0.396 nM for EGFRL858R, EGFRL858R/T790M, EGFRL858R/T790M/C797S, and EGFRLT/L747S, respectively. JBJ-09-063 is…

Cancer

EAI001 is a Selective Mutant EGFR Allosteric Inhibitor

Louis Gilman September 17, 2022

Epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTKs). Specifically, EGFR belongs to a receptor family, which contains three additional proteins, namely ErbB-2, ErbB-3,…

Lung Cancer

BI-1622 is an Orally active and Selective HER2 Inhibitor

Louis Gilman August 16, 2022

BI-1622 is an orally active, potent, and highly selective HER2 (ERBB2) inhibitor, with IC50 values of 7.8, 7.1, <5.3 nM for HER2WT, HER2YVMA, EGFRWT, respectively. Besides, BI-1622 shows greater than 25-fold selectivity…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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