EB1 is a MNK Kinase Inhibitor and Selectively Inhibits the Growth of Cancer Cells
MNKs (Mitogen-activated protein kinase interacting kinases) belong to the family of Ser/Thr kinases, and are classified as members of Ca2+/calmodulin-dependent kinases. MNKs have two different isoforms (MNK1 and MNK2) and play critical roles in the development of human malignancies. MNK1 and MNK2 execute a unique function in regulating eIF4E...
CMLD010509 is a Highly Specific Inhibitor of the Oncogenic MYC-Driven Translation Program
Multiple myelomas (MM) is a hematological malignancy, it exhibits a clonal proliferation of plasma cells in the bone marrow micro-environment. MM remains a frequently incurable hematological malignancy until today. MYC can directly enhance transcription genes encoding ribosomal proteins, ribosomal RNA, and proteins of the translation initiation complex. Furthermore, most...