PND-1186 is a Highly-Specific FAK Inhibitor and Induces Apoptosis
Focal adhesion kinase (FAK) is a tyrosine kinase overexpressed in cancer cells. Especially, FAK plays an important role in the progression of tumors to a malignant phenotype. FAK associates with integrins and modulates various cellular processes including growth, survival, and migration. In particular, PND-1186 is a substituted pyridine reversible...
BI-3663 is a Highly Selective PTK2/FAK PROTAC
Focal adhesion tyrosine kinase (PTK2) is a cytoplasmic protein tyrosine kinase. PTK2 plays an important role in adhesion, spreading, motility, invasion, metastasis, survival, angiogenesis, epithelial to mesenchymal transition, cancer stem cells, and the tumor microenvironment. Overexpression and activation of PTK2 connect with several human malignant diseases, including colorectal, ovarian,...
PF-573228 is a Potent and Selective FAK Inhibitor
Focal adhesion kinase (FAK) is a member of a family of non-receptor protein-tyrosine kinases. The FAK4 family kinases (which include FAK and Pyk2) regulate integrin and growth factor signaling pathways involved in cell migration, proliferation, survival. Besides, FAK expression is increased in many cancers, including breast and prostate cancer....