Tag: FASN

IPI-9119 is an Orally Active, Selective and Irreversible FASN Inhibitor

Fatty acid synthase (FASN) is a multi-enzyme protein that catalyzes the synthesis of fatty acids. Its main function is to catalyze the synthesis of palmitate (C16:0) from acetyl CoA and malonyl COA in the presence of NADPH. Specifically, FASN is a key enzyme responsible for the synthesis of fatty...

TVB-3166 is an Orally Active and Selective FASN Inhibitor

Fatty acid synthases (FASN) are homodimers and multifunctional enzymes that catalyze palmitate biosynthesis in NADPH dependent reactions. FASN plays an important role in tumor cell biology and therapeutic response of various cancer types. In fatty acid synthesis, FASN consumes NADPH, acetyl coenzyme A and malonyl coenzyme A. The consumption of...

FT113 is an Orally Active Inhibitor of Fatty Acid Synthase (FASN)

Fatty acid synthase (FAS) is a protein responsible for fatty acid synthesis. It mainly catalyzes palmitate synthesis from acetyl-CoA and malonyl-CoA, in the presence of NADPH. FAS gene is reported to be a possible oncogene. Many researches also show that FAS exists high levels in breast cancer. The protein...