GBM - Network of Cancer Research

Lomeguatrib is a O⁶-Methylguanine-DNA Methyltransferase (MGMT) Inhibitor

Louis Gilman February 19, 2022

O6-alkylguanine DNA alkyltransferase (also known as AGT, MGMT or AGAT) is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene. MGMT repairs the naturally occurring…

Gliocytoma

JCN037 is a Non-Covalent and Brain-Penetrant EGFR Inhibitor

Louis Gilman June 24, 2020

The epidermal growth factor receptor (EGFR) is a transmembrane protein that is a receptor for members of the EGF family of extracellular protein ligands. In many cancer types, mutations affecting…