Members of the RAS family of GTPases (which comprises KRAS, NRAS, and HRAS) are major oncogenes. Especially, mutations in the RAS genes are major oncogenes with a high occurrence rate in human cancers. RAS-RAF-MEK-ERK and RAS-PI3K-PDK1-AKT pathways are essential to cell survival and proliferation. SOS1 is also the guanine...