Cyclopamine is a Hedgehog (Hh) Pathway Antagonist
Hedgehog (Hh) signal pathway is a signal pathway that transmits information to embryonic cells for appropriate cell differentiation. Specifically, Hedgehog signaling pathway is one of the key regulators of animal development. There are three mammalian Hh proteins, Shh, Indian hedgehog (IHH), and desert hedgehog (DHH). Besides, Shh and IHH...
MRT-83, a Potent Smoothened Antagonist, has Potential to Treat Hh-pathway Related Diseases
The Hedgehog (Hh) signaling pathway participates in developmental processes and multiple physiological responses in adult tissues, including the control of brain functions. Hh pathway activation via an Hh peptide to the 12-pass transmembrane protein Patched (Ptc). However, in the absence of its ligand, repression of the activation of the...