TX1-85-1, a ATP-competitive ligand of Her3, covalent modification of Her3 to inhibit Her3 signaling
Her3 (also known as ErbB3) is a member of the epidermal growth factor receptor (EGFR) tyrosine kinases, including Her1, Her2 and Her4. However, owing to receptor or ligand overexpression or oncogenic mutations that results in constitutive activation of the kinase domain. EGFR family-dependent signaling frequently becomes deregulated in human...