Tag: Histone

Tasisulam, an Antitumor Agent, Inhibits Mitotic Progression and Induces Apoptosis

Tasisulam is an acyl sulfonamide with a unique antitumor dual mechanism of action. It involves antiangiogenesis and mitotic inhibition. Tasisulam has a broad range of activity in 60 tumor cell lines. It includes leukemia, melanoma, non-small-cell lung cancer, colon, ovarian, renal, and breast cancers. In this study, Tasisulam is...

SGC-iMLLT is a Selective Inhibitor of MLLT1/3–Histone Interaction

YEATS domain is a histone acylation reader in health and diseases. There are four YD‐containing genes in humans (MLLT1, YEATS2, MLLT3, and YEATS4). YEATS domain (YD) containing proteins are an emerging class of epigenetic targets in drug discovery. Of these, YEATS2 is a YEATS domain-containing protein conserves from fly...