Tifcemalimab is a Humanized Anti-BTLA Monoclonal Antibody For Cancer Research
The B- and T-lymphocyte attenuator (BTLA) is a co-suppressor receptor for B and T cell expression. HVEM (Herpesvirus Entry Mediator), the main ligand of BTLA, also binds to CD160 and LIGHT. HVEM-BTLA is an important checkpoint for Tumor immune escape. Moreover, the couple inhibits the over-activation of lymphocytes and...
Serplulimab (HLX 10) is humanized monoclonal anti-PD-1 antibody
PD-1 (Programmed cell death protein 1; CD279) is an immune checkpoint. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily. Besides, It shows a role in regulating the immune system’s response by down-regulating the immune system. Meanwhile, this compound promotes self-tolerance by suppressing T-cell inflammatory activity....