PR-619 is a Broad-Range DUB Inhibitor
Ubiquitination is a post-translational modification where the polypeptide ubiquitin is attached to lysine residues of substrate proteins. This process is reversible, and ubiquitin removal is orchestrated by a large family of deubiquitinating enzymes (DUBs). DUBs fall into six subfamilies based on sequence and domain similarity. Ubiquitination and deubiquitination together...
HM03 is a Potent and Selective HSPA5 Inhibitor
Heat shock protein 70 (HSP70) are chaperone proteins that protect proteins from stress and promote nascent polypeptide folding. They exist in both prokaryotic and eukaryotic organisms. The stress-inducible HSP70 is an emerging cancer target that directly inhibits apoptosis. Administration of the inhibitors for HSP90 induces the expression of HSP70....
JG-98 is an Allosteric HSP70 Inhibitor For Cancer Therapy
Heat shock protein 70 (Hsp70/HSPA1A) is a molecular chaperone. It plays important roles in protein homeostasis and cell survival. The expression of Hsp70 strongly correlates with tumor grade, metastasis, and poor prognosis. Thus, it plays a special and broad role in cancer. Hsp70 collaborates with a wide range of...