Tag: HSP70

HM03 is a Potent and Selective HSPA5 Inhibitor

Heat shock protein 70 (HSP70) are chaperone proteins that protect proteins from stress and promote nascent polypeptide folding. They exist in both prokaryotic and eukaryotic organisms. The stress-inducible HSP70 is an emerging cancer target that directly inhibits apoptosis. Administration of the inhibitors for HSP90 induces the expression of HSP70....

JG-98 is an Allosteric HSP70 Inhibitor For Cancer Therapy

Heat shock protein 70 (Hsp70/HSPA1A) is a molecular chaperone. It plays important roles in protein homeostasis and cell survival. The expression of Hsp70 strongly correlates with tumor grade, metastasis, and poor prognosis. Thus, it plays a special and broad role in cancer. Hsp70 collaborates with a wide range of...