CA-5f is a Late-Stage Macroautophagy (Autophagy) Inhibitor for NSCLC Treatment
Currently, discovery of small-molecule modulators of autophagy has become a popular therapy for cancer treatment. A study from Lu Zhang has discovered and identified a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion, CA-5f. Autophagy plays essential roles in various normal cellular processes, including cell proliferation, ageing, and to...
IITZ-01 as a Potent Lysosomotropic Autophagy Inhibitor
Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor (ER) and progesterone receptor (PR). Moreover, human epidermal growth factor receptor overexpression is also absent. The morbidity of TNBC accounts for ~15% of all breast cancers patients. Unfortunately, compared with other breast cancer types, this type of breast cancer...