AZD-9574 is a potent and brain penetrant PARP1 inhibitor
The Poly (ADP-ribose) polymerase (PARP) family has numerous essential functions. PARP plays roles in cellular processes such as transcription, chromatin remodeling, DNA damage response, and repair. DNA double-strand breaks (DSBs) are the most deleterious form of DNA damage. Besides, DSBs can be repaired by homologous recombination repair (HRR) or...
Venadaparib (IDX-1197) is a Potent and Selective PARP Inhibitor
PARP is an enzyme that involved in a number of cellular processes such as DNA repair, and programmed cell death. The PARP family comprises 17 members. They have all very different structures and functions in the cell. Importantly, the main role is to detect and signal single-strand DNA breaks...