Tag: miRNA

RJW100 is a Potent LRH-1 and SF-1 Agonist

Liver receptor homolog 1 (LRH-1, NR5A2) is a member of the nuclear receptor family. Specifically, LRH-1 plays a key role in regulating development, cholesterol transport, bile acid homeostasis, and steroid production. Besides, LRH-1 regulates hepatobiliary acid biosynthesis and cholesterol homeostasis and is the main controller of hepatobiliary. Therefore, the...

Targapremir-210, a Selective miR-210 Inhibitor, Targets the Dicer Site in Pre-miR-210

Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a majority of malignant tumors. Hypoxia associates with tumor progression, resistance to therapy, and metastasis in cancer. Numerous pathways play critical roles in cancer maintenance, including noncoding RNAs such as microRNA (miR)-210 that regulates hypoxia-inducible factors. In...

COH000 is an Allosteric, Covalent and Irreversible Inhibitor of SUMO-Activating Enzyme

Aberrations in post-translational modifications by ubiquitin or ubiquitin-like proteins (Ubl), such as the small ubiquitin-like modifiers (SUMO) relate to the pathogenesis of lifethreatening diseases, such as cancer, neurodegenerative disorders, and viral infection. For instance, emerging studies have identified the dyregulation of SUMOylation in various cancers. Additionally, the SUMO-activating enzyme...