Tag: Mitochondria

AKOS-22, a VDAC1 Oligomerization and Apoptosis Inhibitor, Protects Against Mitochondrial Dysfunction

Apoptosis plays a critical role in several pathological processes, such as neurodegenerative diseases and various cardiovascular diseases. Besides, it is therefore not surprising that mitochondrial dysfunction is associated with various human diseases. Located at the outer mitochondrial membrane (OMM), 2 the voltage-dependent anion channel (VDAC) serves as a mitochondrial gatekeeper. Moreover, the...

Gboxin is an Oxidative Phosphorylation Inhibitor That Targets Glioblastoma

According to the World Health Organization (WHO), Glioblastoma is the most common primary brain neoplasm. It comprises 15% of all intracranial neoplasms and 60-75% of astrocytic tumors. Unfortunately, Glioblastoma is the most aggressive and prevalent primary malignant brain tumor of the central nervous system. Glioblastoma derives specifically from the...