Colon cancer is one of the most common cancers worldwide. Notably, in colon cancer, MKP-1 is overexpressed in the early phases of carcinogenesis. Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a member of dual-specificity phosphatases. MKP-1 inactivates MAPKs by dephosphorylating both their threonine and tyrosine residues. MAPK pathways play important...