M-89, a Specific Menin inhibitor, Has Potential to Treat MLL Leukemia
Mixed lineage leukemia (MLL) protein is a histone methyltransferase and specifically methylates histone H3 lysine 4 residue (H3K4). MLL gene rearrangement accounts 5-10% in acute myeloid leukemia in adults and almost 70% of acute lymphoblastic leukemia in infants. As far as the current treatment regimen is concerned, adult leukemia...
MM-589, a Cell-Permeable Inhibitor of WDR5-MLL Protein Protein Interaction
Acute leukemia is a kind of serious diseases, includes acute myeloid leukemia, acute lymphoblastic leukemia and blast crisis of chronic myelogenous leukemia. MLL1 (Mixed-lineage leukemia 1; KMT2A) is a histone methyltransferase, occurs in leukemia cells in a mutation form. MLL1 interacts with WD repeat domain 5 protein (WDR5), enhances...