Matrix metalloproteinase-3 (MMP-3) plays an important role in the pathology of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). MMP-3 contains a signal peptide, a pro-domain, a catalytic domain, a hinge domain, and a hemopexin domain. Besides, the signal peptide is cleaved off during the secretion process and pro-domain is...