Tanomastat is an Orally Bioavailable, non-Peptidic Biphenyl MMPs Inhibitor
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. The activity of MMPs is thought to be balanced...
SP-8356 is a Potent and Orally Active CD147 Inhibitor
Breast cancer is one of the most fatal diseases in women and exhibits high incidence and mortality among various cancers. Among various signaling pathways that promote tumor growth and progression, an inflammatory transcription factor NF-κB plays pivotal roles on cell proliferation and survival. Interestingly, NF-κB is highly activated in...