Tanomastat is an Orally Bioavailable, non-Peptidic Biphenyl MMPs Inhibitor
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. The activity of MMPs is thought to be balanced...
AC-73 is a Specific and Orally Active CD147 Dimerization Inhibitor
Hepatocellular carcinoma (HCC) is one of the most common cancers. Combating hepatocellular carcinoma invasion and metastasis has become a major desire in hepatocellular carcinoma patients. CD147 (also called EMMPRIN) is a member of the immunoglobulin superfamily. AC-73 is the first specific inhibitor of CD147. In particular, CD147 is a...