The myotonic dystrophy-related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin-myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. A study from Mathieu Unbekandt discovered and identified azaindole compounds BDP8900 and BDP9066 as potent and selective MRCK inhibitors. Both...