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Reliable, unbiased and up to date information in cancer research

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Cancer Lung Cancer Pancreas Cancer

Reversin 121, a P-glycoprotein Inhibitor, Reverses P-glycoprotein-Mediated Multidrug Resistance

Louis Gilman December 1, 2022

Nowadays, how to overcome the resistance of tumor cells to multiple drugs is still a serious problem. Various mechanisms can cause Multidrug resistance (MDR), including cell cycle alterations, increased repair…

Leukemia Solid Tumors

Rosabulin is a Potent Microtubule Inhibitor

Louis Gilman May 1, 2021

Chemotherapy is a cornerstone in the development of present-day cancer therapy. Moreover, Chemotherapy is one of the most effective and potent strategies to treat malignant tumors. However, Chemotherapy resistance occurs…

Cancer

Verucopeptin, a HIF-1 and v-ATPase ATP6V1G Inhibitor, Exhibits Antitumor Activity Against MDR Cancers

Louis Gilman October 20, 2020

ATP6V1G, a subunit of the vacuolar H+-ATPase (v-ATPase). In this article, we will introduce a potent ATP6V1G inhibitor, Verucopeptin. Firstly, in vitro. Verucopeptin shows excellent antitumor activity against K562R cells,…

Acute Leukemia

MPT0B392 Induces Apoptosis via Inhibiting Tubulin Polymerization and Inducing c-JNK Activation

Louis Gilman August 16, 2019

Acute leukemia is a neoplastic disease characterized by a rapid accumulation of primitive hematopoietic cells. MPT0B392 acts as a potential anticancer drug for the treatment of acute leukemia. MPT0B392 is…

Colon Cancer

TTT-28 Antagonizes Multidrug Resistance by Selectively Inhibiting the Efflux Activity of ABCB1

Louis Gilman August 15, 2019

Cancer is a rapidly progressing disease. Chemotherapy is one of the treatment choices apart from surgery and radiation. However, during chemotherapy, a unique phenomenon called multidrug resistance (MDR) emerges. The…

Chronic Myeloid Leukemia

CHMFL-ABL-039, a Selective Type II Native and Drug-Resistant Mutant BCR-ABL Inhibitor for Chronic Myeloid Leukemia

Louis Gilman May 14, 2019

Chronic myeloid leukemia (CML) is a white blood cell disorder, accounting for about 15% of adult leukemias. The critical driving force of pathogenesis of CML identified is BCR gene and…

Breast Cancer Ovary Cancer Pancreas Cancer

SSE15206 is a Microtubule Polymerization Inhibitor

Louis Gilman April 15, 2019

Microtubule, a highly dynamic structure, forms spindle fibers during mitosis. Several key cellular processes such as vesicular trafficking, intracellular signalling, cell motility and mitotic cell division depend on microtubules. In…

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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