Tag: Necroptosis

GW806742X, an ATP mimetic, is a Potent MLKL and VEGFR2 Inhibitor

The pseudokinase Mixed Lineage Kinase domain-like (MLKL) is an essential effector protein in the necroptotic cell death pathway downstream of the protein kinase Receptor Interacting Protein Kinase-3 (RIPK3).  RIPK3–mediated phosphorylation of the activation loop in MLKL trips a molecular switch to induce necroptotic cell death. The structure of mouse MLKL...

HS-1371 is a Small Molecule RIP3 Inhibitor

Necroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Necroptosis plays an important role in many pathological processes such as ischemia-reperfusion injury and host defense against viral infection. Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is a central player in necroptosis, and its kinase activity...