Tag: Necroptosis

HS-1371 is a Small Molecule RIP3 Inhibitor

Necroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Necroptosis plays an important role in many pathological processes such as ischemia-reperfusion injury and host defense against viral infection. Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is a central player in necroptosis, and its kinase activity...