Inorganic elements play crucial roles in biomedical processes. Many inorganic elements such as transition metals have anticancer activities. Even though metal complexes are making progress against cancer, cisplatin (CDDP) remains…
The pseudokinase Mixed Lineage Kinase domain-like (MLKL) is an essential effector protein in the necroptotic cell death pathway downstream of the protein kinase Receptor Interacting Protein Kinase-3 (RIPK3). RIPK3–mediated phosphorylation of…
NUPR1 is an intrinsically disordered protein (IDP) with an entirely disordered conformation. It binds to DNA in a manner similar to other chromatin proteins to control the expression of gene…
Necroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Necroptosis plays an important role in many pathological processes such as ischemia-reperfusion injury and host defense…