Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a master regulator of the cellular antioxidant response. It is genetically activated in Non-Small Cell Lung Cancers (NSCLCs) by, for instance, mutations in the interacting protein KEAP1. Its aberrant activation rewires biochemical networks in cancer cells that may create special vulnerabilities. KEAP1-mutant...