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Reliable, unbiased and up to date information in cancer research

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Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

Louis Gilman September 22, 2023

HDAC inhibitors are a class of anticancer agents. HDAC inhibitors have shown antitumor effects in a variety of cancer cell lines, such as NSCLC, prostate, colon, ovarian, breast, bladder, pancreas,…

Lung Cancer Non-Small Cell Lung Cancer

Osimertinib (AZD9291) is an Orally Active EGFR Inhibitor for Lung Cancer Research

Louis Gilman August 31, 2023

EGFR-mutated (EGFRm+) non-small cell lung cancer (NSCLC) is a major clinical problem. Tyrosine kinase inhibitors (TKIs) have precision therapeutic implications for advanced NSCLC. However, common EGFR mutations, such as EGFRL858R,…

NSCLC

Lorlatinib is an Orally Active ROS1/ALK Inhibitor for NSCLC Research

Louis Gilman July 21, 2023

ROS1 (c-ros oncogene 1) is a receptor tyrosine kinase encoded by the gene ROS1. Importantly, ROS1 is a proto-oncogene and highly expressed in a variety of tumor cell lines, belonging…

Breast Cancer Cancer HER2+ Breast Cancer Lung Cancer Non-Small Cell Lung Cancer

Capivasertib (AZD5363) is an Orally Active and Potent Pan-AKT Kinase Inhibitor

Louis Gilman May 4, 2023

ATR kinase is a key component of the DNA damage response pathway. Additionally, it plays a critical role in maintaining genome stability. Ceralasertib (AZD6738) is a potent inhibitor of ATR…

Cancer Large Cell Lung Cancer Lung Cancer Non-Small Cell Lung Cancer

RMC-6291 is an Orally Active and Covalent KRASG12C Inhibitor for Solid Tumor Research

Louis Gilman April 26, 2023

KRAS  plays a critical role in regulating cell growth and division. KRAS mutations are common in many types of solid tumors, including lung, colon, and pancreatic cancers, and are associated…

Cancer Colorectal Cancer Lung Adenocarcinoma Lung Cancer NSCLC

Sotorasib (AMG-510) is an Orally Bioavailable KRAS G12C Covalent Inhibitor

Louis Gilman March 10, 2023

The KRAS oncoprotein is a GTPase and an essential mediator of intracellular signaling pathways. KRAS oncoprotein regulates tumor cell growth and survival. However, KRAS also is the most frequently mutated…

NSCLC

Talotrexin, A RFC Specific Inhibitor, Targets DHFR to Inhibit Tumor Growth

Louis Gilman February 24, 2023

In this article, we will introduce a potent RFC (reduced folate carrier) specific inhibitor Talotrexin (PT523). Talotrexin, an analog of Aminopterin, is a nonpolyglutamatable classic antifolate. Additionally, it selectively inhibits…

Lung Cancer

Amivantamab (JNJ-61186372) is a Human EGFR-MET Bispecific Antibody

Louis Gilman January 16, 2023

Epidermal growth factor (EGF) is a protein that stimulates cell proliferation, differentiation, and survival by binding to its receptor EGFR. Additionally, It exists in platelets, urine, saliva, milk, tears, and…

Lung Cancer Non-Small Cell Lung Cancer

Adagrasib (MRTX849), a Potent KRAS G12C Inhibitor for KRAS G12C-mutated Locally Advanced or Metastatic NSCLC Research

Louis Gilman December 14, 2022

On December 12, 2022, FDA granted accelerated approval to Adagrasib (Krazati), for adult patients with KRAS G12C-mutated locally advanced or metastatic NSCLC. In 2021, FDA approved the selective KRASG12C mutant…

Cancer Lung Cancer Non-Small Cell Lung Cancer

A947 is a Selective and Efficacious SMARCA2 PROTAC in SMARCA4 Mutant Cancers

Louis Gilman December 13, 2022

SWI/SNF complex has two important ATP-dependent helicases, SMARCA2 and SMARCA4. In fact, SMARCA2 and SMARCA4 share strong protein sequence homology.  But SWI/SNF helicase SMARCA4 is frequently mutated in cancer. The…

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  • Panobinostat is a HDAC Inhibitor for Multiple Myeloma Research

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You Missed

Breast Cancer

BI 7446 is a STING Agonist for Immuno-oncology Research

Gastric Cancer Obesity

JNJ-38877605 is an Orally Active c-Met Inhibitor for Solid Tumour Research

Multiple Myeloma Myeloma

OATD-02 is an Orally Active Arginase 1/2 Inhibitor for Melanoma Research

autoimmune disease

INCB086550 is an Orally Active PD-L1 Inhibitor for Multiple Cancers Research

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